Modern understanding of the role of GABA in the correction of neurocardial pathology
Post updated: July 19
Dyscirculatory encephalopathy (DE) is a chronically occurring vascular disease of the GM, manifested by a disorder of its functions [14-17]. DE is characterized by a complex of diffuse and focal changes in GM caused by the atherosclerotic process. The pathogenesis of atherosclerotic DE is based on cerebral ischemia. Ischemia is accompanied by a decrease in the level of high-energy phosphates, an increase in excitatory amino acids, accumulation of calcium ions inside neurons, morphofunctional disruption of cell membranes, accumulation of free radicals and neurotransmitter imbalance. With DE, the hippocampus, thalamus, pericallosal regions, the lentil-shaped nucleus, some areas of the parietal and temporal cortex, that is, the departments of the GM, which are more responsible for the formation of emotional-mnestic processes and vegetative functions, are more often affected [14, 15]. When determining the strategy of DE therapy, it is necessary to take into account the heterogeneity of the pathogenesis of DE and use drugs with multimodal action (antioxidant, vasoactive, nootropic) .
A study was conducted, the purpose of which was a comprehensive assessment of the effect of the drug Gamalate B6 on the functional state of the central nervous system and the cardiovascular system in patients with stage I-II DE.
Materials and methods of research
An open pilot cohort prospective clinical study, which included 30 patients with stage I-II DE (17 women, 13 men) aged 55 to 75 years (average age – 64.3 ± 5.5 years), was conducted at the clinic of the D.F. Chebotarev Institute of Gerontology of NAMS of Ukraine. The exclusion criteria were as follows: heart failure of functional class III-IV according to the classification of the New York Heart Association, myocardial infarction, acquired heart defects and the presence of concomitant decompensated somatic diseases. Before and after the course of taking Gamalate B6, 1 tablet twice a day for one month, patients underwent a comprehensive clinical, neurological and neuropsychological examination, which included:
assessment of overall functional independence (Bartel index);
assessment of the psycho-emotional state (test "Memorizing 10 words" by A.R. Luria, Munsterberg test);
analysis of bioelectric activity of GM according to electroencephalography (EEG) data on the Neurofax EEG-1100 device (Nihon Kohden, Japan);
examination of cerebral blood flow by ultrasound duplex scanning of the extra- and intracranial sections of the main arteries of the head and neck on the Philips EnVisor device (PHILIPS);
transthoracic echocardiography on a Toshiba Aplio 300 device (Japan);
electrocardiography with assessment of heart rate variability using the Schiller AT-10 plus device (Germany).
Statistical data processing was carried out using the Statistica 6.0 software. The mean value, mean error and statistical significance were calculated using the parametric (Student's t-test) and nonparametric (Pearson'sχ2) method.
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